Clinical pathology
One section, one stain, one answer. Serial slides break spatial context and consume irreplaceable biopsy material.
See Every Signal At Once
Our technology can resolve more than thirty protein markers in one intact tissue section, giving your team spatial proteomics with the clarity of single-plex immunofluorescence.
Tissue has layers. Your stain doesn't.
Every laboratory working with limited tissue faces the same trade: more markers, or more sections. SPECTRE-Plex removes the trade entirely.
Translational cohorts
Marker panels grow faster than sample volume, forcing teams to choose which biology they are willing to lose.
Biopharma discovery
Immune context decides whether a mechanism reads as signal or noise — and it only appears when markers coexist.
The biology you cannot image is the biology you cannot explain.
We are building an imaging platform where spatial truth is preserved — where every marker keeps its coordinates, every cell keeps its neighbours, and one section carries the whole story.
Chemistry, optics and reconstruction tuned as one system, so multiplex depth arrives with less bleed-through, less photodamage, and more confidence in every channel.
PLATFORM
A flexible, modular system
Modular by design
Swap marker panels, cycle counts and reagent modules without re-engineering the workflow — the same cyclic chemistry scales from a pilot panel to a full spatial proteome.
Less hands-on effort
Automated stain and photo-inactivation cycles run unattended on a single mounted section, cutting technician time to a fraction of legacy multiplex protocols.
Higher resolution imaging
An optically invisible microfluidic window delivers high-NA, aberration-free optics, resolving subcellular detail that lower-plex fluorescence methods miss.
Built to scale
Morphology-aware analysis and open data formats carry results straight into any pipeline, from a single slide to translational cohorts run in parallel.
COHORT SCALE
Our Casper Chamber system allows multiple slides with tissue microarrays to be simultaneously stained and imaged with the same multiplex marker panels, allowing rapid and scalable data generation for translational cohorts with minimal batch-to-batch variation.
PATENTED ENGINE
Two components, one instrument
Casper
Patented imaging chamber
A microfluidic “invisi-slip” chamber built around a refractive-index-matched optical window. Any high-NA water-immersion objective mounts without custom optics, so your lab scales marker count and sample throughput on hardware you already run, cycle after automated cycle.
2–12hper 7-cycle run, versus 14–36h for manual methods
ECTO
Patented reagent series
Dye-inactivation and quench chemistry that clears fluorescent signal between rounds orders of magnitude faster than legacy bleach reagents — no gas bubbles, no morphology loss — so panels expand marker by marker without extra hands-on time.
40+cycles run with no measurable tissue deterioration
Invented at Boston Children's Hospital and Harvard Medical School, the Casper chamber and ECTO reagent series were validated together in a peer-reviewed 22-marker, seven-round cyclic imaging panel resolving healthy and active celiac disease duodenal tissue at single-cell resolution.
PEER-REVIEWED
Validated in two peer-reviewed manuscripts
Independent findings in Communications Biology and the Journal of Pathology Informatics confirm our imaging and analysis platform delivers reliable, quantitative results on real diagnostic tissue.
Communications Biology · 2025
SPECTRE-Plex: an automated, high-resolution approach for multiplexed cyclic imaging and tissue spatial analysis
Peer review confirmed the Casper chamber and ECTO reagent chemistry resolve a 22-marker, seven-round panel in eight hours, validated in pediatric celiac disease duodenal tissue.
Journal of Pathology Informatics · 2025
La et al.: A Villus-Crypt Evaluator for automated, quantitative assessment of duodenal mucosal architecture
La and colleagues validated an automated villus-crypt evaluator against our multiplex imaging output, confirming reliable, quantitative scoring of mucosal architecture directly from high-plex tissue scans.
Image the whole section
Send us your experimental scenario and we will work with you on a multiplexed panel and a feasibility read on your own tissue.